Acrylate Category
Data on physico-chemical properties, environmental fate, ecotoxicity, and human health effects have been collected for the following substances: acrylic acid (CAS No. 79-10-7), methyl acrylate (CAS No. 96-33-3), ethyl acrylate (CAS No. 140-88-5), n-butyl acrylate (CAS No. 141-32-2), isobutyl acrylate (CAS No. 106-63-8), tert-butyl acrylate (CAS No. 1663-39-4), and 2-ethylhexyl acrylate (CAS No. 103-11-7). Because these substances exhibit similarity in their physico-chemical properties and toxicological properties in mammals, and because the acrylate esters have been shown to be metabolized in the mammalian body in minutes to acrylic acid and the corresponding alcohol, they can be considered to constitute a chemical category. Data gaps for mammalian toxicity can be addressed by read-across between category members. In addition, because these substances exhibit similarity in their physicochemical, environmental fate and eco-toxicological properties, data gaps in physico-chemical properties and ecotoxicity can be addressed by read-across between category members. The read-across strategy for the endpoints with data-gap was based on the following scenarios in accordance with the RAAF (ECHA, 2017). For more information see: Acrylate Category Summary and Category Justifcation Document for use under EU REACH.