Key Topics
Murine Skin Carcinogenesis and the Role of Immune System Dysregulation in the Tumorigenicity of 2-Ethylhexyl Acrylate
Certain chemicals act as skin carcinogens in humans, and mice are commonly used as models due to similar disease mechanisms. However, susceptibility varies by strain, making single-strain studies unreliable. 2-EHA, an acrylate used in adhesives, paints, and coatings, poses occupational exposure risks but only trace consumer exposure. No human cancers have been linked to 2-EHA, though one mouse strain (C3H/HeJ) showed tumor development. This strain has a Toll-like receptor 4 (TLR4) mutation impairing immune responses, raising concerns about study validity. Issues include high doses, poor histopathology, and lack of reproducibility in other strains. Tumorigenesis likely reflects strain-specific immune dysregulation and chronic inflammation rather than inherent carcinogenicity. Current evidence does not confirm 2-EHA as a skin carcinogen. Future studies should use models mimicking human skin cancers and avoid exceeding tolerated doses. Publication